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2 wherein Xaa is selected from H, a methionine residue or the sequence from -28 to -1 of the protein sequence shown in SEQ No.

1 and the sequences which differ by one or more amino acids and which have the same activity. The present invention accordingly also relates to the DNA sequence.

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Proteins produced by human lymphocytes are described, particularly a protein which is expressed on their surface.

The existence of this protein naturally on T cells has been demonstrated by: - preparation of sera raised against a synthetic peptide representing a region probably exposed to the outside of the FDC c DNA translation product having a protein structure looped, - immunoprecipitation of the LAG-3 protein by anti-peptide heteroantibodies.

The proteins of the invention can further be obtained by other methods of purification of membrane proteins or conventional peptide synthesis or by application of genetic engineering techniques comprising inserting a DNA sequence encoding a protein according to the invention in an expression vector such as a plasmid and transformation of cells with this expression vector and culturing these cells.

The present invention therefore relates to a DNA sequence comprising the nucleotide sequence designated FDC, corresponding to the c DNA sequence shown in SEQ ID No. The translation begins at nucleotide 231 and ends at nucleotide 1724 inclusive.

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It comprises an extracellular region including approximately 420 amino acids and a cytoplasmic region including about 24 amino acids linked by a transmembrane peptide including about 26 amino acids.

It is known that genes of eukaryotic cells exhibit a phenomenon polytypie.